Dr. Tor Yin Sim

Dr. Tor Yin Sim

Lecturer

Ph.D in Pharmacology (Universiti Putra Malaysia)
B.Sc. (Hons) Biomedical Sciences (Universiti Putra Malaysia)

YinSim.Tor@taylors.edu.my
Expertise
  • Drug discovery and development
  • Pharmacology and therapeutics

Research Interests
  • Elucidation of the signaling pathway of anti-cancer compounds
  • Therapeutics in breast cancer
  • Molecular biology/epidemiology of health and diseases particularly cancer

Publications
Peer Reviewed Papers (10 most significant)
  • Ong, Y.S., Yazan, L.S., Ng, W.K., Noordin, M.M., Sapuan, S., Foo, J.B., Tor, Y.S., 2016. Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice. International Journal of Nanomedicine, 2016:11, 5905-5915.
  • Rahman, N.A., Yazan, L.S., Wibowo, A., Ahmat, N., Foo, J.B., Tor, Y.S., Fakurazi, S., 2016. Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231. BMC Complementary and Alternative Medicine, 16(1), 354.
  • Yazan, L.S., Zali, M.F.S.M., Ali, R., Zainal, N.A., Esa, N., Sapuan, S., Ong, Y.S., Tor, Y.S., Gopalsamy, B., Voon, F.L., and Alwi, S.S.S., 2016. Chemopreventive properties and toxicity of kelulut honey in sprague dawley rats induced with azoxymethane. BioMed Research International, 2016: 1-6.
  • Foo, J.B., Yazan, L.S., Tor, Y.S., Wibowo, A., Ismail, N., Armania, N., Loh, S.P., Ismail, I.S., Cheah, Y.K. and Abdullah, R. 2016. Dillenia suffruticosa dichloromethane root extract induced apoptosis towards MDA-MB-231 triple-negative breast cancer cells. Journal of Ethnopharmacology, 187: 195-204.
  • Yazan, L.S., Rahman, N. A., Chan, K. W., Ghani, W. N. H. W. A., Tor, Y. S. and Foo, J. B. 2016. Phenolics-saponins rich fraction of defatted kenaf seed meal exhibits cytotoxicity towards cancer cell lines. Asian Pacific Journal of Tropical Biomedicine. 6(5): 404-409.
  • Hafiza, W. A. G. W. N., Yazan, L. S., Tor, Y. S., Foo, J. B., Armania, N. and Rahman, H. S. 2016. Endoplasmic reticulum stress-induced apoptotic pathway and mitochondrial dysregulation in HeLa cells treated with dichloromethane extract of Dillenia suffruticosa. Pharmacognosy Magazine, 12(Suppl 1), S86–S95.
  • Yazan L.S., Ong, Y.S., Zaaba, N.E., Ali, R.M., Foo, J.B. and Tor Y.S. 2015. Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice. Asian Pacific Journal of Tropical Biomedicine. 5(12):1018-26.
  • Tor, Y.S., Latifah, S.Y., Foo, J.B., Wibowo, A., Ismail, N., Cheah, Y.K., Abdullah, R., Ismail, M., Ismail, I.S. and Yeap, S.K. 2015. Induction of apoptosis in MCF-7 cells via oxidative stress generation, mitochondria-dependent and caspase-independent pathway by ethyl acetate extract of Dillenia suffruticosa, and its chemical profile. PLoS One, 10(6): e0127441.
  • Tor, Y.S., Latifah, S.Y., Foo, J.B., Armania, N., Cheah, Y.K., Abdullah, R., Imam, M.U., Ismail, N. and Ismail, M. 2014. Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa. BMC Complementary and Alternative Medicine, 14: 1-12.
  • Foo, J.B., Yazan, L.S., Tor, Y.S., Wibowo, A., Ismail, N., Armania, N., Loh, S.P., Ismail, I.S., Cheah, Y.K., Abdullah, R. 2015. Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway. Journal of Ethnopharmocology, 166: 270-278
  • Foo, J.B., Latifah, S.Y., Tor, Y.S., Armania, N., Ismail, N., Imam, M.U., Yeap, S.K., Cheah, Y.K., Abdullah, R. and Ismail, M. 2014. Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signaling pathways. BMC Complementary and Alternative Medicine, 14: 1-16.
  • Armania, N., Latifah, S.Y., Ismail, I.S., Foo, J.B., Tor, Y.S., Ishak, N., Ismail, N. and Ismail, M. 2013. Dillenia suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis. Molecules, 18: 13320-13339.
  • Hamizah, S., Roslida, A.H., Fezah, O., Tan, K.L., Tor, Y.S. and Tan, C.I. 2012. Chemopreventive potential of Annona muricata L. leaves on chemically-induced skin papillomagenesis in mice. Asian Pacific Journal of Cancer Prevention, 13: 2533-2539.

Conference Abstracts/Proceedings (10 most significant):
  • Tor, Y.S., Lye, M. S., Rozita, R., Johnson, S., Ibrahim, N., Loh, S. P., Ling, K. H. Vitamin D receptor polymorphisms and risk of Major Depressive Disorder. The 29th World Congress of the International Association for Suicide Prevention (IASP) and The 21st Malaysian Conference on Psychological Medicine (MCMP), 18th-22nd July 2017, Kuching, Sarawak, Malaysia.
  • Tor, Y.S., Latifah, S.Y., Foo, J.B., Armania, N., Ismail, N., Imam, M.U., Yeap, S.K., Cheah, Y.K., Abdullah, R. and Ismail, M. Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa. Proceeding of the 5th International Conference on Natural Products for Health and Beauty (NATPRO 5) (6th-8th May 2014), Moevenpick Resort & Spa Karon Beach Phuket, Phuket, Thailand.
  • Foo, J.B., Latifah, S.Y., Tor, Y.S., Armania, N., Ismail, N., Imam, M.U., Yeap, S.K., Cheah, Y.K., Abdullah, R. and Ismail, M. Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways. Proceeding of the 5th International Conference on Natural Products for Health and Beauty (NATPRO 5) (6th-8th May 2014), Moevenpick Resort & Spa Karon Beach Phuket, Phuket, Thailand.
  • Wan Abd Ghani, W.N.H., Latifah, S.Y., Foo, J.B., Tor, Y.S., Armania, N. and Rahman, H.S. Dillenia suffruticosa extracts inhibits proliferation of cervival cancer cells via G2/M arrest and apoptosis through mitochondrial dysregulation and endoplasmic reticulum stress-induced apoptosis. Proceeding of the 5th International Conference on Natural Products for Health and Beauty (NATPRO 5) (6th-8th May 2014), Moevenpick Resort & Spa Karon Beach Phuket, Phuket, Thailand.

Scholarly Activities/ Industry Experience (10 most significant):
  • Post-doctoral Researcher in Universiti Putra Malaysia (April 2016 – August 2017)
  • Facilitator of Nanomedicine Workshop (2015-2016), Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia.
  • Facilitator of Animal Cell Culture and Flow Cytometry Workshop (2013-2014), Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia.

Awards & Honours
  • Good Clinical Practice Certificate (2016), National Committee for Clinical Research
  • Best Paper Award (Third Prize). The 29th World Congress of the International Association for Suicide Prevention (IASP) and The 21st Malaysian Conference on Psychological Medicine (MCMP), 18th-22nd July 2017, Kuching, Sarawak, Malaysia.
  • Best Graduate Student, 2015. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
  • Best Poster Presentation Award. The 5th International Conference on Natural Products for Health and Beauty, 6-8th May 2014, Phuket, Thailand.

Professional Affiliations
  • Malaysian Natural Products Society (Member)
  • Malaysian Society of Pharmacology and Physiology (Member)