Dr Aditya Arya

Dr Aditya Arya

Senior Lecturer
School of Medicine
Faculty of Health and Medical Sciences

PhD in Pharmacology (University of Malaya)
MPharm (Dr M G R Medical University)
BPharm (Rajiv Gandhi University of Technology)

aditya.arya@taylors.edu.my
Subject Taught
  • Clinical & Experimental Pharmacology
  • Therapeutics & New Advancements in Drug Therapy
  • Drug Discovery
  • Theranostics

Research Interests
  • Cellular & Molecular Pharmacology
  • Drug Discovery for Diabetes, Obesity, Cancer and Neurological Disorders
  • In vitro study designs & in vivo experimental models of rodents and zebrafish
  • Development of aptamers in diagnostic and therapeutic applications for the target disorders

Research Grants Awarded
  • Role of Carvone on multiple mechanism of obesity and cardiac dysfunction in FFAs-treated H9c2 myotubes: in vitro metabolic pathways. Principal Investigator (PI), 2017, Taylor’s University Major Research Grant (TRGS), Malaysia: Project No: TRGS/MFS/2/2016/SOM/003. RM 46,800
  • A therapeutic intervention with Scutellarin, targeting the high lipogenic diet-induced metabolic heart disease in obese mice. Principal Investigator (PI), 2014, Fundamental Research Grant (FRGS), Ministry of Higher Education (MOHE), Malaysia: Project No: FP021-2014A. RM 142,080
  • Role of natural products on the stimulation of glucose transporter (GLUT) protein and AMP kinase activation for the target of type 2 diabetes. Principal Investigator (PI), 2013, University of Malaya Research Grant (UMRG), Malaysia: Project No: RP001D-13BIO. RM 198,000
  • Attenuating Influenza A Virus Endocytosis By HB-EGF (Heparin-Binding EGF-Like Growth Factor). Co-Investigator, 2015, Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education (MOHE), Malaysia: Project No: FRGS 1/2015. RM 187,800/li>
  • Evaluation of the potential bioactivities of edible bird nests (EBN) extract using in vitro and in vivo models in the management of type 1 and type 2 diabetes. Co-Investigator (CI), 2015, Department of Veterinary under Ministry in collaboration with Royal Bird’s Nest Sdn Bhd, Malaysia: Project No. RM 180,000
  • Bioactive Compounds from Malaysian Plants, Co-Investigator, 2012, High Impact Research Grant (HIR): Ministry of Higher Education (MOHE) Project No: (UM-MOHE UM.C/625/1/HIR/MOHE/09), RM 15 Million
  • Evaluation of natural triterpenoid on the obesity associated cardiac dysfunction: Targeting ER stress pathway in obese mice-fed with lipogenic diet. Principal Investigator (PI), 2014, University of Malaya Research Grant (UMRG), Malaysia: Project No: RP021A-14AFR. RM 70,000
  • Targeting phytochemicals on kidney dysfuntion in the human mesangial cell and diet-induced insulin resistant mice model. Principal Investigator (PI), 2014, University of Malaya Research Grant (UMRG), Malaysia: Project No: RP021D-14AFR. RM 70,000
  • Investigating the antidiabetic effect of Chlorophytum borivilianum extracts on pancreatic RIN-5F cells and type 2 diabetic rats by targeting GLP-1 and DPP-4. Principal Investigator (PI), 2015: University of Malaya Research Grant (UMRG), Project No: PG039-2014B. RM 22,500
  • Anticancer potential of Tanacetum parthenium and Urtica dioica on five targeted cell lines with possible mechanism. Principal Investigator (PI): BKP Project (IPPP) from University of Malaya, 2011. Project No: BKP: 21 (2012), RM 30,000
  • Pharmacological and toxicological evaluation of isolated constituents for the free radical scavenging and antidiabetic activity from natural occurring plant product (extracts) in normal and diabetic rats. Post Graduate Student Research Grant, University of Malaya: 2010: Project No: PG051:2010, RM 15,000
Publications
2017
  • Hamed Karimian, Aditya Arya, Mehran Fadaeinasab, Mohamad Ibrahim Noordin. 2017. Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo. Drug Design, Development and Therapy. (ISI-Cited Publication)
2016
  • Siti Hajar Adam, Aditya Arya, Naguib Salleh. 2016. Protective effect of aqueous seed extract of Vitis Vinifera against oxidative stress, inflammation and apoptosis in the pancreas of adult male rats with diabetes mellitus. Biomedicine and Pharmacotherapy. 81 (2016) 439–452 (ISI-Cited Publication)
  • Siti Hajar Adam, Aditya Arya, Pharkphoom Panichayupakaranant, Praveen Kumar Korla and Naguib Salleh. 2016. Rhinacanthin C ameliorates hyperglycemia, hyperlipidemia and pancreatic destruction in streptozotocin-nicotinamide induced adult male diabetic rats. European Journal of Pharmacology. 771 (2016) 173 190 (ISI-Cited Publication)
2015
  • Suresh Kumar Ananda Sadagopan, Aditya Arya, Hamed Karimian and Mohd Rais Mustafa. (2015). Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo. Journal of Experimental and Clinical Cancer Research: 2015; (ISI-Cited Publication)
  • Aditya Arya, Ataul Karim Khan, Nayiar Shahid, Abu Sadat Sayem, Chung Yeng Looi, Mohd Rais Mustafa, Mustafa Ali Mohd, Hapipah Mohd Ali. Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin-nicotinamide induced diabetic rat. Journal of Ethnopharmacology: 2015; (ISI-Cited Publication)
  • Fatemeh Hajiaghaalipour, Manizheh Khalilpourfarshbafi, Aditya Arya. Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus: International Journal of Biological Sciences: 2015; 11(5): 508-524. doi: 10.7150/ijbs.11241 (ISI-Cited Publication)
  • Hairin Taha, Chung Yeng Looi, Aditya Arya, Ian C Paterson, Hapipah Mohd Ali. (6E,10E) Isopolycerasoidol nd (6E,10E) Isopolycerasoidol Methyl Ester, Prenylated Benzopyran Derivatives from Pseuduvaria monticola Induce Mitochondrial-Mediated Apoptosis in Human Breast Adenocarcinoma Cells. PlosOne: 2015 Doi:10.1371/journal.pone.0126126 (ISI-Cited Publication)
  • Fatemeh Ahmadipour, Mohamed Ibrahim Noordin, Syam Mohan, Aditya Arya, Chung Lip Yong. 2015. Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44+/CD24-/low): an in vitro study. Drug Design, Development and Therapy 2015:9 1193 1208 (ISI-Cited Publication)
  • Soon Huat Tiong, Chung Yeng Looi, Aditya Arya, Mohd Rais Mustafa, Khalijah Awang: Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G.Don (Apocynaceae): Fitoterapia 2015doi: 10.1016/j.fitote.2015.01.019. (ISI-Cited Publication)
2014
  • Aditya Arya, Nayiar Shahid, Mohamed Ibrahim Bin Noordin, Chung Yeng Looi, Won Fen Wong, Mohd Rais Mustafa: Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study. Food and Chemical Toxicology: 2014: 71(2014)183 196. (ISI-Cited Publication)
  • Hairin Taha, Aditya Arya, Hapipah Mohd. Ali, Mustafa A.M, A.Hamid A.Hadi: Upregulation of insulin secretion and downregulation of pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats by Pseuduvaria monticola bark extract: Food and Chemical Toxicology: 2015: 10.1016/j.fct.2014.01.054. (ISI-Cited Publication)
  • Hamed Karimian, Aditya Arya, Mahmood Ameen Abdulla, Syam Mohan, Hapipah Mohd Ali, Mohamad Ibrahim Noordin: Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27: Drug Design, Development and Therapy: 2014:8 1481 1497 (ISI-Cited Publication)
  • Abdulwali Ablat,Jamaludin Mohamad,Khalijah Awang, Jamil A. Shilpi and Aditya Arya: Evaluation of Antidiabetic and Antioxidant Properties of Brucea javanica Seed: The Scientific World Journal: 2014 doi.org/10.1155/2014/786130 (ISI-Cited Publication)
  • Mohamed Ibrahim Noordin, Chung Lip Yong, Mofat,I, Zainuddin,Z, Aditya Arya and Shaik Nyamathulla, 2014, Evaluation of Palm oil-based Paracetamol suppositories by DIfferential Scanning Calorimetry: Tropical Journal of Pharmaceutical Research: 2014: 13(1);23-29. (ISI Cited Publication)
2013
  • Aditya Arya, Chung Yeng Looi., Won Fen Wong., Mohamed Ibrahim Noordin., Shaik Nyamathulla., Mohd Rais Mustafa & Mustafa Ali Mohd: In vitro antioxidant, PTP-1B inhibitory effects and in vivo hypoglycemic potential of selected medicinal plants: International Journal of Pharmacology: 2013: doi:10.3923/ijp.2013. (ISI Cited Publication)
  • Chung Yeng Looi, Aditya Arya, Foo Kit Cheah, Bushra Muharram, Kok Hoong Leong, Khalit Mohamad, Won Fen Wong, Nitika Rai, Mohd Rais Mustafa: Induction of Apoptosis in Human Breast Cancer Cells via Caspase Pathway by Vernodalin Isolated from Centratherum anthelminticum (L.) Seeds: PlosOne: 2013: 8(2) doi:10.1371/journal.pone.0056643: (ISI Cited Publication)
  • Chung Yeng Looi, Bushra Moharram, Mohammadjavad Paydar, Yi Li Wong, Kok Hoong Leong, Khalit Mohamad, Aditya Arya, Won Fen Wong and Mohd Rais Mustafa. Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways: BMC Complementary and Alternative Medicine: 2013, 13:166. doi:10.1186/1472- 6882-13-166 (ISI-Cited Publication)
  • Soon Huat Tiong, Chung Yeng Looi, Hazrina Hazni, Aditya Arya, Mohammadjavad Paydar, Won Fen Wong, Shiau-Chuen Cheah, Mohd Rais Mustafa and Khalijah Awang. Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.): Molecules: 2013, (ISI-Cited Publication)
  • Mohammadjavad Paydar, Bushra Abdulkarim Moharam, Yi Li Wong, Chung Yeng Looi, Won Fen Wong, Shaik Nyamathulla, Vijayapandi Pandy, Behnam Kamalidehghan and Aditya Arya: Centratherum anthelminticum (L.) Kuntze a potential medicinal plant with pleiotropic pharmacological and biological activities: International Journal of Pharmacology: 2013: (ISI Cited Publication)
2012
  • Aditya Arya, Shiau-Chuen Cheah, Chung-Yeng Looi, Hairin Taha, Mohd. Rais Mustafa and Mustafa Ali Mohd. 2012. The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats: Food and Chemical Toxicology: 2012 (ISI Cited Publication)
  • Aditya Arya, Chung Yeng Looi, Shiau Chuen Cheah, Mohd Rais Mustafa and Mustafa Ali Mohd. 2012. Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats: Journal of Ethnopharmacology: 2012 (ISI Cited Publication)
  • Aditya Arya, Mohd Rais Mustafa and Mustafa Ali Mohd. 2012. Chloroform fraction of Centratherum anthelminticum (L.) seed inhibits tumor necrosis factor alpha and exhibits pleotropic bioactivities: inhibitory role in human tumor cells. Evidence-Based Complementary and Alternative Medicine: 2012:doi:10.1155/2012/627256 (ISI Cited Publication)
  • Ismail Adam Arbab, Chung Yeng Looi, Aditya Arya, Manal Mohamed Elhassan Taha, Bushra Muharram, Mohd Rais Mustafa and Siddig Ibrahim Abdelwahab: Dentatin induces apoptosis in prostate cancer cells via Bcl-2, Bcl-xL, Survivin downregulation, caspase-9, -3/7 activation and NF-?B inhibition: Evidence-Based Complementary and Alternative Medicine: 2012: (ISI Cited Publication)
  • Aditya Arya, Mahmood Ameen Abdullah, B.S Haerian and Mustafa Ali Mohd.2012.Screening for hypoglycemic activity on the leaf extracts of nine medicinal plants: in-vivo evaluation. E-Journal of Chemistry.2012, 9(3), 1196-1205 (ISI Cited Publication)
2011-2010
  • Aditya Arya, Batoul Sadat Haerian and Mustafa Ali Mohamad, Antihyperglycemic effect of Centratherum anthelminticum, Terminalia chebula and Terminalia bellirica extracts, The Journal of the Federation of American Societies for Experimental Biology (FASEB Journal): 2010,4,960. (ISI-Cited Publication)
  • Aditya Arya, Shaik Nyamathulla, Mohamed Ibrahim Noordin, Mustafa Ali Mohd: Antioxidant and hypoglycemic activities of leaf extracts of three popular Terminalia species: E-Journal of Chemistry: 2011, 9(2), 883-892 (ISI Cited Publication)

Patent Intellectual Property Rights
  • Patent Application No. : PI2015700502: Vernodalin used to modulate AKT/FOXO3A/BIM pathway for apoptosis of human breast cancer cells

Conference Abstracts/Proceedings
  • In vivo antidiabetic and antioxidant potential of Pseudovaria macrophylla extract. Oral presentation at International Conference in Pharmacy and Pharmacology (ICPP 2014): September 26-27 2014, London, United Kingdom
  • Quercetin and quinic acid synergistically downregulates inflammatory response in the liver and kidney of lipopolysaccharide induced rats: Targeting diabetes and inflammation. Oral presentation at Australian Diabetes Society and the Australian Diabetes Educators Association Annual Scientific Meeting (ADS-ADEA-ASM 2014) 26th-29th August 2014 at Melbourne Convention and Exhibition Centre, Melbourne
  • Bioactive compounds of some Malaysian Annonaceae species. Oral presentation at 4th International Conference on Advance in Biotechnology and Pharmaceutical Sciences (ICABPS’2013) held in Singapore on 12-13 October 2013 Woodfordia fruticosa flower extract upregulate insulin secretion and downregulates pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats. Oral presentation at 65th Indian Pharmaceutical Congress: 20-22 December 2013 at New Delhi, India

Scholarly Activities
  • Research Fellow at IPharm (Malaysian Institutes of Pharmaceuticals and Nutraceuticals): October 2015-present
  • External Examiner, PhD Thesis, Dr M G R Medical University
  • Internal Examiner, PhD Thesis, University of Malaya
  • Travel Award (TA) to attend American Society for Pharmacology and Experimental Therapeutics (ASPET) conference held in Anaheim, California, United States of America (USA) in 2010

Industry Experience
  • Research Scientist at Amritum Bio-Botanica Herbs Research Laboratory Pvt. Ltd, India. January 2002-June 2003

Professional Affiliations
  • American Society for Pharmacology and Experimental Therapeutics
  • British Pharmacology Society
  • Australian Society of Clinical and Experimental Pharmacologists and Toxicologists