Distinguished Lecture Series by Professor Simon Croft

Date: 16 & 18 January 2017 (Monday & Wednesday)
Venue: Taylor’s University, Lakeside Campus

Professor Simon Croft is a Professor of Parasitology at the Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine and has worked on the discovery and development of anti-infective drugs for over 35 years in academia, industry and with public-private partnerships.

Research focus:
  • Identification and evaluation of novel drugs and formulations for the treatment of leishmaniasis, malaria, human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease);
  • Anti-malarials included several MMV supported discovery and pre-clinical projects;
  • PK PD relationships, predictive models for drugs and vaccines, topical formulations and drug resistance;
  • Neglected Infectious Diseases
Drug R&D for Intracellular Pathogens – Drug Distribution, PK PD and Selectivity

New drugs and treatments for diseases caused by intracellular pathogens, like tuberculosis and leishmaniasis, have proved to be some of the most difficult to discover and develop. The focus of much research has been on the identification of potent and selective compounds that inhibit target enzymes (or other essential molecules) or are active against the causative pathogen in an in vitro assay. Although these discovery paradigms remain an essential part of the drug R&D pathway, over the past decade, additional emphasis has been given to the challenges that ensure these active compounds, the potential novel anti-infective drugs reach the target pathogen, within the host cell, with appropriate distribution to the infected tissue / organ and there exert the appropriate effect. Different routes of administration also require different thinking about pharmacokinetics and pharmaceutics. This talk will focus on how these challenges are being met by those working on intracellular pathogens. Come and join the talk on the following date:
Date: 16 January 2017 (Monday)
Time: 2.30pm - 3.30pm
Venue: Lecture Room C6.04

Research and Development for Neglected Tropical Disease through Partnerships

In view of the new landscape that has emerged for neglected tropical diseases, Prof. Simon will look at principles for developing successful collaborating networks and partnerships and the engagement of academia, public-private partnerships and the private sector in research and innovation. Selected examples whereby these principles have had an impact on global health, innovation and intellectual property will also be shown. He will discuss the interactions between those involved in the Research and Development of diagnostics, drugs and vaccines, and those who are involved in the implementation of tools, policy and practice in the context of Africa, Asia and South America. It is essential to understand the reasons for success and failure, and that lessons learned are not only communicated to funders, but also to ministries, health workers and populations affected. Come and listen to him as he delivers his talk on the following date:
Date: 18 January 2017 (Wednesday)
Time: 3pm - 5pm
Venue: Lecture Theatre 12