IVF today looks vastly different from its early days. What was once experimental has become a highly refined process supported by decades of scientific research and clinical improvements.

Time-Lapse Imaging (EmbryoScope)

Think of it as a baby monitor for embryos—but far more advanced. Time-lapse imaging allows embryologists to watch embryos develop in real time, without ever disturbing their carefully controlled environment. Systems like EmbryoScope take thousands of high-resolution images over several days, creating a detailed timeline of development.

This technology helps clinicians catch critical—but subtle—clues, such as how evenly cells divide or whether development is on schedule. These details can make all the difference when selecting which embryo has the highest chance of becoming a healthy baby.

Why It Matters:

• Reduces handling and maintains ideal conditions for embryo growth.
• Tracks precise developmental milestones to better predict embryo health.
• Increases chances of success by improving embryo selection.

_{Time-lapse systems can capture up to 5,000 images per embryo, helping embryologists uncover patterns invisible to the human eye.}

Preimplantation Genetic Testing (PGT)

Behind every embryo is a genetic blueprint. PGT lets fertility specialists take a closer look—screening for chromosomal abnormalities or inherited conditions before implantation. It’s a powerful way to match hope with health. Types of PGT include:

• PGT-A (Aneuploidy): Screens for extra or missing chromosomes (e.g., Down syndrome).
• PGT-M (Monogenic): Detects specific inherited diseases like cystic fibrosis or thalassaemia.
• PGT-SR (Structural Rearrangements): Identifies chromosomal translocations and other abnormalities.

Why It Matters:

• Boosts the chances of a successful, healthy pregnancy.
• Reduces risk of miscarriage by avoiding embryos with chromosomal errors.
• Supports families with known genetic conditions in having healthy children.

^{PGT can be especially helpful for women over 35, when the risk of chromosomal abnormalities naturally increases.}

Assisted Hatching (AH)

Before an embryo can implant in the uterus, it has to ‘hatch’ from its protective outer layer—the zona pellucida. But sometimes, that outer shell is just too tough. That’s where assisted hatching comes in.

Using a fine laser or specialised chemical solution, clinicians create a tiny opening in the shell to help the embryo break free and attach to the uterine lining. It’s a delicate nudge that can make a world of difference, especially in older patients or those with previous IVF failures.

Why It Matters:

• May improve implantation chances in selected cases.
• Helps embryos with thick or hardened outer shells.
• Offers renewed hope to patients with a history of failed cycles.

_{Assisted hatching has evolved from manual microneedles and acid solutions to precision lasers—now the go-to method for helping embryos 'break out' and implant, much like giving nature a high-tech nudge. Image Source: inviTRA}